- Human gut microbiota is a dynamic and complex microbial system that is link to the pathogen colonization resistance, regulation of the immune system, and maintenance of human health. Quorum Sensing (QS) plays an essential role on the microbe-host symbiosis of natural microbial systems. QSHGM, a database of QS in Human Gut Microbiota includes 28,567 redundancy removal QS synthases and receptors entries of 818 gut microbes.